Cover Image, Volume 190, Number 1, March 2022

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American Journal of Medical Genetics Part C: Seminars in GeneticsVolume 190, Issue 4 p. i-i COVER IMAGEFree Access Cover Image, Volume Number 1, March 2022 First published: 06 January 2023 https://doi.org/10.1002/ajmg.c.31929AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have read accept the Wiley Online Library UseShareable LinkUse link a this article with your friends colleagues. Learn more.Copy URL Abstract image: RASopathy genes role their encoded proteins RAS-MAPK signaling cascades. Cartoon lists implicated RASopathies year discovery. Genes requiring further clinical delineation and/or functional validation context are shown red. Milestones linked these discoveries also reported. D R indicate dominant recessive, respectively. Below figure gene discovery timeline, cascade showing signal flow through pathway (black arrows), together positively (blue) negatively (red) controlling cascade, is presented. P Ub phosphorylation ubiquitination, For explanations see Figure 1 legend from paper by Tartaglia et al. (present issue). Image shows pictures some individuals affected RASopathies. Volume190, Issue4Special Issue: Molecular advances, management, treatment opportunities RASopathiesDecember 2022Pages RelatedInformation

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ژورنال

عنوان ژورنال: American Journal of Medical Genetics Part C: Seminars in Medical Genetics

سال: 2022

ISSN: ['1552-4868', '1552-4876']

DOI: https://doi.org/10.1002/ajmg.c.31929